Recombinant Human Angiopoietin-like 7, FLAG-tagged ANGPTL7-410H

Recombinant Human Angiopoietin-like 7, FLAG-tagged


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Cat.No. : ANGPTL7-410H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human ANGPTL7 (angiopoietin-like protein 7) (aa 1-346) produced inHEK 293 cellsis fused at the N-terminus to a FLAG-tag.
Description : Human ANGPTL7 is produced as a secreted glycoprotein with a molecular mass of 45kDa in SDS-PAGE analysis. Human mRNA is expressed in neural tissues, keratoconus cornea, trabecular meshwork, melanotic melanoma and uterus endometrial cancer, while mouse Angptl7 mRNA is expressed in four-cell embryos, synovial fibroblasts, thymus, uterus and testis. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by inducing massive fibrosis in a mouse xenograft model. It was reported that addition of ANGPTL7 results in a further increase in HSC activities. This suggests that ANGPTL7 may activate signal transduction pathways that cannot be activated by SCF, TPO, IGF-2 or FGF-1. Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signalling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine.
Source : HEK293 cells.
Purity : ≥90% (SDS-PAGE).
Formulation : Liquid. 0.2µm-filtered solution in PBS.
Concentration : ~0.5mg/ml.
Endotoxin Content : <0.1EU/µg protein (LAL-test).
Long Term Storage : -20°C.
Use/Stability : Working aliquots are stable for up to 3 months when stored at -20°C.
Handling : After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : ANGPTL7 angiopoietin-like 7 [ Homo sapiens ]
Synonyms : angiopoietin-like 7; AngX; CDT6; dJ647M16.1; RP4-647M16.2; ANGPTL7; angiopoietin-like protein 7; angiopoietin-related protein 7; angiopoietin-like factor (CDT6); cornea-derived transcript 6 protein;Angiopoietin-like factor; Cornea-derived transcript 6 protein
Gene ID : 10218
mRNA Refseq : NM_021146
Protein Refseq : NP_066969
UniProt ID : O43827
Chromosome Location : 1p36.3-p36.2
Function : receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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