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Recombinant Human Annexin A9, T7-tagged

Cat.No. : ANXA9-69H
Product Overview : Recombinant Human annexin 9 produced inE.coliis a non-glycosylated, polypeptide chain containing amino acids (1-338) and having a total molecular mass of 38.9 kDa. rhANXA9 contains T7 tag at N-terminus and is purified by proprietary chromatographic techniques.
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  • Gene Information
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Cat. No. : ANXA9-69H
Description : The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. The most striking feature of annexin 31 is a complete ablation of all four homologous type II calcium-binding sites in the conserved tetrad core. Although all 4 type II calcium-binding sites in annexin 31 contained amino acid substitutions that ablated their function, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.
Source : Escherichia coli.
Physical Appearance : Sterile Filtered clear solution.
Purity : Greater than 95.0% as determined by the analysis by reducing and non-reducing SDS-PAGE coomassie blue staining.
Formulation : Recombinant Human Annexin-9 at a concentration of 0.1mg containing 10 mM Tris, pH 8.0, 0.1% Triton X-100 and 0.002% NaN3.
Applications : •ELISA • MS• Western Blotting.
Storage : RhAnnexin-9 although stable at 14°Cfor 1 week, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : ANXA9 annexin A9 [ Homo sapiens ]
Synonyms : ANXA9; annexin A9; ANX31;Annexin A9; Annexin-9; Annexin-31; Annexin XXXI; OTTHUMP00000033027; Pemphaxin
Gene ID : 8416
mRNA Refseq : NM_003568
Protein Refseq : NP_003559
MIM : 603319
UniProt ID : O76027
Chromosome Location : 1q21
Function : calcium ion binding; calcium-dependent phospholipid binding; acetylcholine receptor activity; phosphatidylserine binding; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (17)

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Can ANXA9 be regulated by post-translational modifications? 04/28/2023

The specific post-translational modifications (PTMs) of ANXA9 have not been extensively studied. However, it is plausible that ANXA9 undergoes PTMs, such as phosphorylation or acetylation, that may affect its function and interactions. Further research is needed to uncover the PTMs that modulate ANXA9.

Can ANXA9 be used as a therapeutic target? 12/29/2022

It is not yet clear whether ANXA9 can be directly targeted therapeutically. Further research is required to elucidate its precise function, molecular mechanisms, and potential contribution to disease pathways to determine its viability as a therapeutic target.

Are there any known animal models or knockout studies for ANXA9? 09/10/2022

As of now, there are no widely reported animal models or knockout studies specifically targeting ANXA9. However, generating ANXA9 knockout animal models or conducting related experiments may provide valuable insights into its biological functions and potential implications in disease mechanisms.

Are there any known genetic variants or mutations in the ANXA9 gene? 05/30/2022

There is limited information regarding genetic variants or mutations in the ANXA9 gene. Comprehensive studies investigating ANXA9 gene variations and their potential impact on disease susceptibility or phenotype are necessary to expand our understanding of the genetic landscape.

Are there any known drugs or therapies targeting ANXA9? 03/24/2021

Currently, no drugs or therapies specifically targeting ANXA9 have been developed or approved. However, as our understanding of ANXA9's biological functions and its involvement in diseases grows, it may pave the way for potential therapeutic strategies in the future.

Does ANXA9 have any known functions in normal physiological processes? 05/24/2020

ANXA9 is believed to play a role in normal physiological processes, although the full extent of its functions is not yet clear. It is thought to have roles in cellular processes such as membrane dynamics, vesicle trafficking, and calcium signaling. However, more research is needed to fully understand its normal physiological functions.

Is ANXA9 expressed in all tissues or organs? 12/29/2019

ANXA9 is expressed in various tissues and organs, although the specific expression pattern and levels may vary. It has been detected in tissues such as the brain, heart, lung, liver, kidney, and colon. Further studies are needed to determine the precise expression pattern of ANXA9 in different tissues and its potential roles.

How is ANXA9 regulated at the gene expression level? 09/02/2018

The regulation of ANXA9 gene expression has not been extensively studied. However, it is likely to be regulated by various transcription factors and epigenetic modifications, as is the case with other genes. Further research is needed to uncover the specific regulatory mechanisms that control ANXA9 expression.

Does ANXA9 have any known binding partners or ligands? 01/31/2018

The complete repertoire of ANXA9 binding partners or ligands is not yet fully characterized. However, as a member of the annexin family, ANXA9 may interact with calcium ions, phospholipids, and other protein partners involved in cellular processes like membrane dynamics and signal transduction.

Does ANXA9 have any known interactors or binding partners? 07/27/2017

ANXA9 has been shown to interact with various proteins and molecules. Some of its known interactors include members of the annexin family, such as ANXA1 and ANXA2. It has also been reported to interact with proteins involved in vesicular trafficking and membrane dynamics, such as AP2M1 and RAB5C. Additionally, ANXA9 has been found to bind to phospholipids, specifically phosphatidylserine and phosphatidylcholine. However, more research is needed to fully understand the protein-protein interactions and binding partners of ANXA9.

Is ANXA9 associated with any specific types of cancer? 01/17/2017

ANXA9 has been implicated in various types of cancer, including breast cancer, lung cancer, and colorectal cancer. However, the extent of its involvement and its specific role in each cancer type are still being investigated.

Can ANXA9 be used as a diagnostic or prognostic marker for cancer? 07/23/2016

ANXA9 has been proposed as a potential diagnostic and prognostic marker for certain types of cancer. Several studies have found that decreased expression of ANXA9 is associated with poor prognosis in breast cancer, lung cancer, and colorectal cancer. Additionally, ANXA9 expression has been suggested as a potential biomarker for prediction of treatment response and disease progression. However, more research is needed to validate its utility as a diagnostic or prognostic marker, and standardized testing methods would need to be established.

Can ANXA9 be used as a diagnostic or prognostic marker for any diseases? 07/18/2016

Currently, there is no specific diagnostic or prognostic utilization of ANXA9 established in clinical practice. However, ongoing research exploring the potential correlation between ANXA9 expression levels and various diseases may shed light on its diagnostic or prognostic value in the future.

What are the potential future research directions for ANXA9? 06/12/2016

Future research on ANXA9 could focus on further elucidating its molecular mechanisms and functions in cancer and other diseases. This could involve studying its interactions with other proteins and regulatory factors, investigating its impact on cellular processes such as membrane dynamics and vesicular trafficking, and exploring its potential as a therapeutic target. Additionally, more studies could be conducted to validate its utility as a diagnostic or prognostic marker in various cancer types.

Are there any known interactions of ANXA9 with other proteins? 06/04/2016

There is limited information available regarding the protein-protein interactions of ANXA9. However, like other annexin family members, ANXA9 may interact with specific binding partners, including regulatory proteins and components of the cellular membrane. Further research is needed to identify these interacting proteins and understand their functional relevance.

Is ANXA9 associated with any diseases? 04/23/2016

The involvement of ANXA9 in diseases is not well-established and requires further investigation. Nevertheless, some studies have suggested its potential association with certain pathological conditions, including cancer, cardiovascular diseases, and autoimmune disorders. More research is necessary to establish the exact role of ANXA9 in disease development and progression.

Where is ANXA9 expressed? 03/21/2016

ANXA9 is expressed in multiple tissues and organs, including the brain, heart, lung, liver, kidney, and skeletal muscle. Its expression may vary across different cell types and developmental stages.

Customer Reviews (5)

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Reviews
12/10/2022

    the manufacturer's dedication to continuous improvement and innovation is evident in their ongoing efforts to enhance the ANXA9 protein's performance and optimize its applications.

    01/20/2020

      The exceptional quality and reliability of the ANXA9 protein provided by the manufacturer cannot be overstated.

      12/22/2019

        Their team of experts is not only knowledgeable about the ANXA9 protein but is also dedicated to assisting researchers like myself in overcoming any challenges that may arise.

        08/04/2018

          This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.

          06/14/2016

            Its purity and consistency guarantee accurate and consistent results, allowing for confident data interpretation and analysis.

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