| Description : |
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
38.3 kDa |
| AA Sequence : |
MATAERRALGIGFQWLSLATLVLIC AGQGGRREDGGPACYGGFDLYFILD KSGSVLHHWNEIYYFVEQLAHKFIS PQLRMSFIVFSTRGTTLMKLTEDRE QIRQGLEELQKVLPGGDTYMHEGFE RASEQIYYENRQGYRTASVIIALTD GELHEDLFFYSEREANRSRDLGAIV YCVGVKDFNETQLARIADSKDHVFP VNDGFQALQGIIHSILKKSCIEILA AEPSTICAGESFQVVVRGNGFRHAR NVDRVLCSFKINDSVTLNEKPFSVE DTYLLCPAPILKEVGMKAALQVSMN DGLSFISSSVIITTTHCSDGSILAI ALLILFLLLALALLWWFWPLCCTVI IKEVPPPPAEESEENKIKTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
