Recombinant Human AOC1 Protein, MYC/DDK-tagged

• Cat.No.: AOC1-2320H
• Product Overview: Recombinant human AOC1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Description: This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 83.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: AOC1 amine oxidase, copper containing 1 [ Homo sapiens ]
• Official Symbol: AOC1
• Synonyms: ABP; ABP1; DAO; DAO1; KAO
• Gene ID: 26
• mRNA Refseq: NM_001091.3
• Protein Refseq: NP_001082.2
• MIM: 104610
• UniProt ID: P19801

Reviews

07/10/2021

AOC1 still maintains its original stability after repeated freezing and thawing, which is very conducive to our experiment.

09/20/2019

High purity can reduce the error in the experiment and improve the repeatability of the experiment.

07/20/2019

The resolution of AOC1 in Western blot is high, which can distinguish similar protein molecular weights.

Q&As

How should the dose of AOC1 be determined?

The dosage should be determined based on a combination of factors such as the patient's age, physical condition and severity of the condition.

Can AOC1 be taken orally?

No oral formulation has been developed and can only be administered by injection or intravenous drip.

What are the adverse reactions of AOC1 ?

Mild adverse reactions such as drowsiness, headache, and nausea may occur, and in severe cases, allergic reactions and elevated blood pressure may occur.

What are the preservation conditions of AOC1 ?

The storage temperature is usually -20°C to avoid repeated freezing and thawing and exposure to light.

How to evaluate the efficacy of AOC1 ?

Efficacy evaluation needs to be carried out according to the pathophysiological characteristics and treatment criteria of different diseases.

How can AOC1 be further promoted and popularized?

Large-scale clinical research and economic evaluation are needed, as well as publicity and science popularization.

What is the action mechanism of AOC1?

AOC1 can promote the protection and repair of cardiovascular system and nervous system by regulating the level of angiotensin (Ang II), and inhibit tumor growth and deterioration.

How reproducible is AOC1 ?

Reproducibility needs to be enhanced through multi-center clinical trials and product quality monitoring.

Does the use of AOC1 with other drugs affect the effect?

The possibility of interaction needs to be assessed on a patient-specific basis.

What is the bioavailability of AOC1 ?

It needs to be evaluated according to different formulations and modes of administration.

How does AOC1 get approved through clinical trials?

It needs to be proven safe and effective in tightly controlled clinical trials and then submitted to drug regulators.

Can AOC1 be used for long-term therapy?

Long-term treatment options need to be evaluated according to the characteristics and treatment criteria of different diseases.

Can AOC1 replace existing drugs?

Substitutability and advantages of different diseases need to be evaluated according to their characteristics and treatment criteria.

What are the limitations of AOC1 in clinical application?

No large-scale clinical studies have been conducted, and further confirmation of its potential safety and efficacy is needed.

In what diseases might AOC1 play a role?

Recombinant AOC1 may play a role in the treatment of cancer, cardiovascular disease and neurodegenerative diseases.

What is the production process of AOC1 ?

The production process usually includes gene cloning, transfection, expression, purification and other steps.