Recombinant Human APLNR Protein, GST-tagged
Cat.No. : | AGTRAP-448H |
Product Overview : | Human AGTRAP partial ORF ( NP_065083, 108 a.a. - 159 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 31.46 kDa |
AA Sequence : | HMYRERGGELLVHTGFLGSSQDRSA YQTIDSAEAPADPFAVPEGRSQDAR GS |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AGTRAP angiotensin II receptor-associated protein [ Homo sapiens ] |
Official Symbol : | AGTRAP |
Synonyms : | AGTRAP; angiotensin II receptor-associated protein; type-1 angiotensin II receptor-associated protein; ATRAP; AT1 receptor-associated protein; ATI receptor-associated protein; angiotensin II, type I receptor-associated protein; MGC29646; |
Gene ID : | 57085 |
mRNA Refseq : | NM_001040194 |
Protein Refseq : | NP_001035284 |
MIM : | 608729 |
UniProt ID : | Q6RW13 |
Products Types
◆ Recombinant Protein | ||
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AGTRAP-224R | Recombinant Rat AGTRAP Protein, His (Fc)-Avi-tagged | +Inquiry |
AGTRAP-7915Z | Recombinant Zebrafish AGTRAP | +Inquiry |
◆ Lysates | ||
AGTRAP-8968HCL | Recombinant Human AGTRAP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionYes, dysregulation of AGTRAP expression or function has been implicated in various cardiovascular conditions, including hypertension, cardiac hypertrophy, and heart failure.
Yes, AGTRAP can regulate AGTR1 expression by influencing its trafficking and degradation, thus impacting the overall abundance of AGTR1 receptors.
AGTRAP can modulate AGTR1 signaling by affecting the receptor's coupling to downstream signaling pathways, including G proteins and β-arrestins.
AGTRAP is widely expressed in various tissues, including the heart, kidney, liver, and brain.
AGTRAP acts as a negative regulator of AGTR1, thereby modulating the effects of angiotensin II on blood pressure control and vascular function.
AGTRAP is primarily localized in the endoplasmic reticulum (ER) and Golgi apparatus, where it interacts with AGTR1 during receptor maturation and trafficking.
AGTRAP physically associates with AGTR1 and modulates its activity by influencing receptor trafficking, signaling, and desensitization.
While the precise involvement of AGTRAP in specific diseases is still being elucidated, dysregulation of AGTRAP has been associated with cardiovascular diseases, hypertension, and altered response to angiotensin II.
AGTRAP has been reported to interact with several proteins involved in receptor trafficking, including G protein-coupled receptor-associated sorting proteins (GASP), which influence AGTR1 cell surface expression.
Techniques such as immunoprecipitation, co-immunoprecipitation, fluorescence microscopy, and genetic manipulation in cellular and animal models are employed to investigate AGTRAP's role and molecular mechanisms.
Customer Reviews (5)
Write a reviewIt was delivered quickly, and the product was of exceptional quality, meeting all my research needs.
Outstanding products. Impressive results!
The protein I purchased was a game-changer for my experiments. Its high activity and purity significantly improved the reliability of my findings
Reliable and high-quality protein. Recommended!
I've been using proteins for years, and this one ranks among the best.
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