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Recombinant Human APOBEC2 protein, His-tagged

Cat.No. : APOBEC2-19H
Product Overview : Recombinant Human APOBEC2, fused with N-His, was expressed in E. coli.
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  • Gene Information
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Description : Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Source : E.coli
Species : Human
Tag : His
Form : 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0.
Molecular Mass : 27.6kDa
Protein length : 239aa
Applications : WB, ELISA, IP, antibody production, protein array
Storage : Store at -80°C and avoid repeated freeze-thaw cycles.
Gene Name : APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 [ Homo sapiens ]
Official Symbol : APOBEC2
Synonyms : APOBEC2; ARCD1; ARP1
Gene ID : 10930
mRNA Refseq : NM_006789
Protein Refseq : NP_006780
MIM : 604797
UniProt ID : Q9Y235
Pathway : RNA binding; cytidine deaminase activity; hydrolase activity; metal ion binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Can APOBEC2 protein be targeted with specific drugs or inhibitors? 02/10/2023

Due to limited understanding of APOBEC2's function and its relevance to diseases, there are currently no known specific drugs or inhibitors that target APOBEC2 protein. Further research is necessary to elucidate its role and potential therapeutic targets, if any.

Can APOBEC2 protein influence RNA stability or degradation? 11/24/2022

The impact of APOBEC2 protein on RNA stability or degradation has not been widely investigated. However, some research suggests that APOBEC2 may interact with proteins involved in RNA decay pathways, indicating its potential role in modulating RNA stability. Further studies are needed to elucidate the precise mechanisms and extent of APOBEC2's involvement in RNA stability or degradation processes.

Are there any known interacting partners of APOBEC2 protein? 08/10/2022

The interacting partners of APOBEC2 protein are not extensively characterized. However, it has been reported to interact with APOBEC1 and potentially modulate its editing activity. Additionally, it may interact with other proteins involved in RNA metabolism, leading to potential functional implications for APOBEC2 in RNA processing.

Can APOBEC2 protein edit its own mRNA? 08/10/2022

The ability of APOBEC2 to edit its own mRNA has not been extensively studied. However, there is evidence suggesting that APOBEC2 may undergo self-editing, similar to other members of the APOBEC family. Further research is needed to determine the extent and significance of self-editing by APOBEC2.

Does APOBEC2 protein have any non-editing functions? 01/16/2021

While the primary function of APOBEC2 is not well established, studies suggest that it may have non-editing functions. It has been implicated in processes like myogenesis and muscle development. APOBEC2 may be involved in regulating gene expression or protein interactions beyond its editing activity.

Does APOBEC2 protein have any role in viral defense or immune response? 11/03/2020

The involvement of APOBEC2 protein in viral defense or immune response is not well established. While other APOBEC family members, such as APOBEC3 proteins, are known to have antiviral activity, APOBEC2's potential role in this context is still largely unexplored. Further studies are needed to determine if APOBEC2 contributes to viral defense mechanisms or immune response pathways.

Can APOBEC2 protein be targeted for therapeutic interventions? 08/05/2020

The therapeutic targeting of APOBEC2 protein has not been extensively explored. However, given its potential involvement in cellular processes and diseases, it might serve as a target for therapeutic interventions in the future. Developing specific inhibitors or modulators of APOBEC2 activity could be a potential avenue of research for therapeutic purposes.

Does APOBEC2 protein play a role in lipid metabolism like APOBEC1? 09/25/2019

While APOBEC1 is known to regulate lipid metabolism through its editing activity on APOB mRNA, the role of APOBEC2 in lipid metabolism is not well characterized. Further studies are required to determine if APOBEC2 has any direct impact on lipid metabolism or if its functions are mainly related to other cellular processes.

Is APOBEC2 protein essential for embryonic development? 08/23/2019

The role of APOBEC2 protein in embryonic development is not fully understood. Studies in mice have shown that APOBEC2 is expressed during early embryogenesis in various tissues. However, further research is required to determine if APOBEC2 plays a crucial role in embryonic development, and if its absence results in any notable developmental abnormalities.

Is APOBEC2 protein expressed in all tissues? 04/29/2019

APOBEC2 protein exhibits tissue-specific expression patterns. It is found in various tissues, including skeletal muscle, heart, and brain. However, the exact distribution and levels of APOBEC2 expression in different tissues are not fully characterized.

How is the expression of APOBEC2 regulated? 04/21/2018

The regulation of APOBEC2 expression is not fully understood. It is known that APOBEC2 expression is regulated by various genetic and epigenetic factors. For instance, certain transcription factors and signaling pathways may influence APOBEC2 expression levels. However, more studies are required to unravel the precise mechanisms of APOBEC2 regulation.

Are there any known regulatory mechanisms that control APOBEC2 protein activity? 02/12/2018

The regulatory mechanisms controlling APOBEC2 protein activity remain largely unknown. It is still unclear if APOBEC2 undergoes post-translational modifications or if it requires specific cofactors for its activity. More research is needed to identify the regulatory mechanisms that govern APOBEC2 protein function and activity.

Can APOBEC2 protein be used as a diagnostic or prognostic marker for any diseases? 11/04/2017

Currently, there are no validated diagnostic or prognostic applications of APOBEC2 protein. However, as more knowledge about its functions and associations with diseases is acquired, there is potential for APOBEC2 to be explored as a biomarker in certain diseases. Future research may shed light on its diagnostic or prognostic relevance in specific contexts.

Is APOBEC2 protein involved in any diseases? 04/15/2017

The association of APOBEC2 protein with diseases is currently unclear. Unlike other members of the APOBEC family, APOBEC2 has not been extensively studied in the context of disease pathogenesis. More research is needed to determine if APOBEC2 plays a significant role in any specific disease processes.

Are there any known mutations in the APOBEC2 gene associated with diseases? 10/10/2016

Currently, there are no well-established disease-causing mutations identified in the APOBEC2 gene. However, genetic variations in APOBEC2 have been studied in relation to certain conditions, such as obesity and muscle-related disorders. Further research is needed to understand the potential implications of these genetic variations on disease susceptibility or pathogenesis.

Can APOBEC2 protein be used as a potential drug target for therapeutic development? 05/29/2016

The potential of APOBEC2 protein as a drug target has not been extensively investigated. As our understanding of its role and involvement in diseases expands, it may be explored as a target for therapeutic development. However, significant research is required to determine the feasibility and efficacy of targeting APOBEC2 for therapeutic purposes.

Is APOBEC2 protein involved in cancer development or progression? 04/10/2016

The involvement of APOBEC2 protein in cancer is not well understood. However, several other members of the APOBEC family, like APOBEC3 proteins, have been implicated in cancer due to their ability to mutate DNA. It remains to be determined if APOBEC2 has similar implications in cancer biology, and further studies are required to explore its role, if any, in cancer development or progression.

Are there any known genetic or environmental factors that affect APOBEC2 expression or activity? 01/22/2016

The factors influencing APOBEC2 expression or activity are not well characterized. It is likely that both genetic and environmental factors can influence APOBEC2 levels or its functional activity. Further research is needed to identify the specific factors that modulate APOBEC2 expression or activity and understand their impact on physiological processes or disease outcomes.

Customer Reviews (4)

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Reviews
02/18/2022

    The reliable and high-quality results obtained using APOBEC2 protein make it an excellent choice for researchers studying protein structures.

    12/31/2021

      This enhanced visibility and distinctness of the protein bands greatly aided in the accurate analysis and interpretation of my Western Blotting results.

      12/12/2020

        Its reliability, versatility, and ability to deliver clear and reliable results make it a top choice for researchers in need of a high-quality protein for their experiments.

        12/12/2020

          APOBEC2 protein has exhibited remarkable performance in Western Blotting experiments.

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