Recombinant Human APOBEC3A, GST-tagged

• Cat.No.: APOBEC3A-9753H
• Product Overview: Recombinant Human APOBEC3A protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-61a.a.
• Description: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A [ Homo sapiens ]
• Official Symbol: APOBEC3A
• Synonyms: APOBEC3A; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; ARP3; phorbolin I; PHRBN
• Gene ID: 140561
• MIM: 607109
• UniProt ID: P31941
• Chromosome Location: 22q13.1-q13.2