Recombinant Human ARC, His-tagged

• Cat.No.: ARC-7572H
• Product Overview: Recombinant human ARC protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Antigen Description: Activity-regulated cytoskeleton-associated protein, also known as ARC, is required for consolidation of synaptic plasticity as well as formation of long-term memory. This protein regulates endocytosis of AMPA receptors in response to synaptic activity. This protein required for homeostatic synaptic scaling of AMPA receptors. This protein plays a role in the regulation of cell morphology and cytoskeletal organization.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
• Molecular Mass: 47.4 kDa (416aa) confirmed by MALDI-TOF
• Protein length: 1-396aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE
• Purity: >90% as determined by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: ARC activity-regulated cytoskeleton-associated protein [ Homo sapiens ]
• Official Symbol: ARC
• Synonyms: ARC; activity-regulated cytoskeleton-associated protein; Arg3.1; KIAA0278; ARC/ARG3.1; activity-regulated gene 3.1 protein homolog
• Gene ID: 23237
• mRNA Refseq: NM_015193
• Protein Refseq: NP_056008
• MIM: 612461
• UniProt ID: Q7LC44
• Chromosome Location: 8q24.3
• Pathway: Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem