| Description : |
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
90.09 kDa |
| AA Sequence : |
MGKVLREENQCIAPVVSSRVSPGTR PTAMGSFSSHMTEFPRKRKGSDSDP SQEAHSQTEKRRRDKMNNLIEELSA MIPQCNPMARKLDKLTVLRMAVQHL RSLKGLTNSYVGSNYRPSFLQDNEL RHLILKTAEGFLFVVGCERGKILFV SKSVSKILNYDQASLTGQSLFDFLH PKDVAKVKEQLSSFDISPREKLIDA KTGLQVHSNLHAGRTRVYSGSRRSF FCRIKSCKISVKEEHGCLPNSKKKE HRKFYTIHCTGYLRSWPPNIVGMEE ERNSKKDNSNFTCLVAIGRLQPYIV PQNSGEINVKPTEFITRFAVNGKFV YVDQRATAILGYLPQELLGTSCYEY FHQDDHNNLTDKHKAVLQSKEKILT DSYKFRAKDGSFVTLKSQWFSFTNP WTKELEYIVSVNTLVLGHSEPGEAS FLPCSSQSSEESSRQSCMSVPGMST GTVLGAGSIGTDIANEILDLQRLQS SSYLDDSSPTGLMKDTHTVNCRSMS NKELFPPSPSEMGELEATRQNQSTV AVHSHEPLLSDGAQLDFDALCDNDD TAMAAFMNYLEAEGGLGDPGDFSDI QWTL |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
