Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ARSF protein, GST-tagged

Cat.No. : ARSF-864H
Product Overview : Human ARSF full-length ORF ( NP_004033.2, 1 a.a. - 590 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of the subfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting that they are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone and cartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jan 2011]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 92.3 kDa
AA Sequence : MRPRRPLVFMSLVCALLNTCQAHRV HDDKPNIVLIMVDDLGIGDLGCYGN DTMRTPHIDRLAREGVRLTQHISAA SLCSPSRSAFLTGRYPIRSGMVSSG NRRVIQNLAVPAGLPLNETTLAALL KKQGYSTGLIGKWHQGLNCDSRSDQ CHHPYNYGFDYYYGMPFTLVDSCWP DPSRNTELAFESQLWLCVQLVAIAI LTLTFGKLSGWVSVPWLLIFSMILF IFLLGYAWFSSHTSPLYWDCLLMRG HEITEQPMKAERAGSIMVKEAISFL ERHSKETFLLFFSFLHVHTPLPTTD DFTGTSKHGLYGDNVEEMDSMVGKI LDAIDDFGLRNNTLVYFTSDHGGHL EARRGHAQLGGWNGIYKGGKGMGGW EGGIRVPGIVRWPGKVPAGRLIKEP TSLMDILPTVASVSGGSLPQDRVID GRDLMPLLQGNVRHSEHEFLFHYCG SYLHAVRWIPKDDSGSVWKAHYVTP VFQPPASGGCYVTSLCRCFGEQVTY HNPPLLFDLSRDPSESTPLTPATEP LHDFVIKKVANALKEHQETIVPVTY QLSELNQGRTWLKPCCGVFPFCLCD KEEEVSQPRGPNEKR
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ARSF arylsulfatase F [ Homo sapiens ]
Official Symbol : ARSF
Synonyms : ARSF; arylsulfatase F; ASF;
Gene ID : 416
mRNA Refseq : NM_001201538
Protein Refseq : NP_001188467
MIM : 300003
UniProt ID : P54793

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (9)

Ask a question
Are there any known interactions between the ARSF protein and other molecules? 07/16/2022

The ARSF protein may interact with various molecules within the cellular environment. For example, it has been reported to interact with other sulfatases, transporters of sulfate-containing molecules, and certain signaling proteins. These interactions can regulate its activity or contribute to different physiological processes and pathways involving sulfate metabolism.

Are there any therapeutic strategies being explored for ARSF-related disorders? 01/13/2022

Therapeutic strategies for ARSF-related disorders such as CDPX2 are still limited. However, some approaches are being explored, including gene therapy, enzyme replacement therapy, and small molecule modulators to restore or enhance ARSF protein function. These strategies hold promise but require further research and development.

How does the ARSF protein differ from other sulfatase enzymes? 06/24/2021

The ARSF protein belongs to the sulfatase enzyme family, which includes several other members involved in sulfate metabolism. Each sulfatase enzyme functions on different substrates and has distinct tissue distribution. While the ARSF protein shares similarities with other sulfatases, it has its specific characteristics and plays a unique role in the hydrolysis of certain sulfate esters.

Can the ARSF protein be used as a diagnostic or prognostic marker for certain diseases? 06/05/2021

Currently, the ARSF protein is not widely used as a specific diagnostic or prognostic marker for diseases beyond its association with CDPX2. However, as research progresses and our understanding of the ARSF protein expands, it is possible that it may be utilized in the future for diagnostic, prognostic, or even therapeutic purposes in certain diseases or conditions.

What are the potential roles of the ARSF protein beyond sulfate metabolism? 06/09/2020

While the ARSF protein is primarily known for its involvement in sulfate metabolism, emerging research suggests it may have additional functions. Some studies have suggested that ARSF may play a role in cell adhesion and migration processes, potentially influencing tissue development and repair. Further research is needed to fully understand these additional roles.

Are there any known diseases or conditions associated with ARSF protein dysregulation? 10/30/2019

Currently, the primary disorder associated with ARSF protein dysregulation is X-linked chondrodysplasia punctata type 2 (CDPX2). This disorder results from mutations in the ARSF gene, leading to deficient or impaired ARSF protein activity. However, there may be other diseases or conditions that involve ARSF dysregulation, and ongoing research continues to investigate its potential involvement in various disorders.

How is ARSF protein deficiency diagnosed? 12/20/2017

ARSF protein deficiency, specifically CDPX2, can be diagnosed through genetic testing. A blood or saliva sample is usually collected to analyze the DNA and identify mutations in the ARSF gene. Additionally, clinical evaluation and radiographic imaging may be used to confirm the diagnosis.

Is there a treatment available for ARSF protein deficiency or CDPX2? 04/18/2017

Currently, there is no specific cure for ARSF protein deficiency or CDPX2. Treatment is usually focused on managing the symptoms and complications associated with the condition. This may include interventions such as physical therapy for skeletal abnormalities, cataract surgery, and supportive care for intellectual disability and other associated issues.

What happens when the ARSF protein is mutated or dysfunctional? 11/18/2016

Mutations in the ARSF gene can lead to a deficiency or reduced activity of the ARSF protein. This can result in a condition called chondrodysplasia punctata, specifically X-linked chondrodysplasia punctata type 2 (CDPX2). CDPX2 is characterized by skeletal abnormalities, cataracts, intellectual disability, and other features.

Customer Reviews (3)

Write a review
Reviews
09/14/2022

    Its reliability and effectiveness in generating accurate data make it an indispensable resource, driving scientific exploration and advancing our understanding of protein structure and function

    02/26/2017

      Researchers can rely on the ARSF protein to deliver precise results, enhancing the credibility and efficiency of their experiments.

      03/09/2016

        By incorporating the ARSF protein into electron microscopy studies, researchers gain insights into the intricate three-dimensional architecture of proteins, facilitating a deeper comprehension of their functions and aiding in the development of novel therapeutics.

        Ask a Question for All ARSF Products

        Required fields are marked with *

        My Review for All ARSF Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends