| Description : |
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
51.7 kDa |
| AA Sequence : |
MASESGKLWGGRFVGAVDPIMEKFN ASIAYDRHLWEVDVQGSKAYSRGLE KAGLLTKAEMDQILHGLDKVAEEWA QGTFKLNSNDEDIHTANERRLKELI GATAGKLHTGRSRNDQVVTDLRLWM RQTCSTLSGLLWELIRTMVDRAEAE RDVLFPGYTHLQRAQPIRWSHWILS HAVALTRDSERLLEVRKRINVLPLG SGAIAGNPLGVDRELLRAELNFGAI TLNSMDATSERDFVAEFLFWASLCM THLSRMAEDLILYCTKEFSFVQLSD AYSTGSSLMPQKKNPDSLELIRSKA GRVFGRCAGLLMTLKGLPSTYNKDL QEDKEAVFEVSDTMSAVLQVATGVI STLQIHQENMGQALSPDMLATDLAY YLVRKGMPFRQAHEASGKAVFMAET KGVALNQLSLQELQTISPLFSGDVI CVWDYGHSVEQYGALGGTARSSVDW QIRQVRALLQAQQASGPTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
