| Description : |
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6 |
| Source : |
E. coli |
| Tag : |
His |
| Form : |
Lyophilized from a 0.2 µM filtered solution of PBS, pH 7.4. |
| Molecular Mass : |
30.3kD |
| AA Sequence : |
MEDSHKSTTSETAPQPGSAVQGAHI SHIAQQVSSLSESEESQDSSDSIGS SQKAHGILARRPSYRKILKDLSSED TRGRKGDGENSGVSAAVTSMSVPTP IYQTSSGQYIAIAPNGALQLASPGT DGVQGLQTLTMTNSGSTQQGTTILQ YAQTSDGQQILVPSNQVVVQTASGD MQTYQIRTTPSATSLPQTVVMTSPV TLTSQTTKTDDPQLKREIRLMKNRE AARECRRKKKEYVKCLENRVAVLEN QNKTL |
| Endotoxin : |
Endotoxin level is <0.1 ng/µg of protein (<1EU/µg). |
| Purity : |
>95% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration : |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
