Recombinant Human ATL1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ATL1-1062H
• Product Overview: ATL1 MS Standard C13 and N15-labeled recombinant protein (NP_056999) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 63.4 kDa
• AA Sequence: MAKNRRDRNSWGGFSEKTYEWSSEE EEPVKKAGPVQVLIVKDEHSFELDE TALNRILLSEAVRDKEVVAVSVAGA FRKGKSFLMDFMLRYMYNQESVDWV GDYNEPLTGFSWRGGSERETTGIQI WSEIFLINKPDGKKVAVLLMDTQGT FDSQSTLRDSATVFALSTMISSIQV YNLSQNVQEDDLQHLQLCTEYGRLA MEETFLKPFQSLIFLVRDWSFPYEF SYGADGGAKFLEKRLKVSGNQHEEL QNVRKHIHSCFTNISCFLLPHPGLK VATNPNFDGKLKEIDDEFIKNLKIL IPWLLSPESLDIKEINGNKITCRGL VEYFKAYIKIYQGEELPHPKSMLQA TAEANNLAAVATAKDTYNKKMEEIC GGDKPFLAPNDLQTKHLQLKEESVK LFRGVKKMGGEEFSRRYLQQLESEI DELYIQYIKHNDSKNIFHAARTPAT LFVVIFITYVIAGVTGFIGLDIIAS LCNMIMGLTLITLCTWAYIRYSGEY RELGAVIDQVAAALWDQGSTNEALY KLYSAAATHRHLYHQAFPTPKSEST EQSEKKKMTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ATL1 atlastin GTPase 1 [ Homo sapiens (human) ]
• Official Symbol: ATL1
• Synonyms: ATL1; atlastin GTPase 1; spastic paraplegia 3A (autosomal dominant), SPG3, SPG3A; atlastin-1; AD FSP; atlastin; FSP1; GBP-3; hGBP3; GTP-binding protein 3; guanylate-binding protein 3; spastic paraplegia 3 protein A; brain-specific GTP-binding protein; guanine nucleotide-binding protein 3; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1
• Gene ID: 51062
• mRNA Refseq: NM_015915
• Protein Refseq: NP_056999
• MIM: 606439
• UniProt ID: Q8WXF7