Recombinant Human ATN1, His-tagged

Species :	Human
Source :	E.Coli/Yeast
Tag :	His
Protein Length :	1190
Description :	Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.
Form :	This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Purity :	>90%
Notes :	Small volumes of ATN1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage :	Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer :	PBS pH 7.4, 50% glycerol
Warning :	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Name	ATN1 atrophin 1 [ Homo sapiens ]
Official Symbol	ATN1
Synonyms	ATN1; atrophin 1; D12S755E, dentatorubral pallidoluysian atrophy (atrophin 1) , DRPLA; atrophin-1; B37; dentatorubral-pallidoluysian atrophy protein; HRS; NOD; DRPLA; D12S755E;
Gene ID	1822
mRNA Refseq	NM_001007026
Protein Refseq	NP_001007027
MIM	607462
UniProt ID	P54259
Chromosome Location	12p
Function	JUN kinase binding; protein binding; protein domain specific binding; toxin receptor binding; transcription corepressor activity;