Recombinant Human Aurora Kinase C, GST-tagged, Active

• Cat.No.: AURKC-248H
• Product Overview: Recombinant full-length human AURORAC was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 61 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. Aurora C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors. Aurora C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. Aurora C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: AURKC aurora kinase C [ Homo sapiens ]
• Synonyms: aurora kinase C; AIE2; AIK3; ARK3; AurC; STK13; aurora-C; AURKC; aurora/IPL1/EG2 protein 2; aurora/IPL1-related kinase 3; serine/threonine kinase 13 (aurora/IPL1-like); EC 2.7.11.1; Aurora-C; Aurora/Ipl1-related kinase 3; Aurora/Ipl1/Eg2 protein 2
• Gene ID: 6795
• mRNA Refseq: NM_001015878
• Protein Refseq: NP_001015878
• MIM: 603495
• UniProt ID: Q9UQB9
• Chromosome Location: 19q13.43
• Function: protein serine/threonine kinase activity; ATP binding; nucleotide binding; transferase activity