Recombinant Human AZIN1 Protein, 1-448, C-IgG1 Fc-Avi-tagged, Biotinylated

• Cat.No.: AZIN1-01H
• Product Overview: Biotinylated recombinant Human AZIN1 Protein (1-448) with C-IgG1 Fc-Avi-tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene.
• Source: HEK293
• Species: Human
• Tag: C-IgG1 Fc-Avi
• Molecular Mass: 77 kDa
• Protein Length: 1-448
• AA Sequence: MKGFIDDANYSVGLLDEGTNLGNVI DNYVYEHTLTGKNAFFVGDLGKIVK KHSQWQNVVAQIKPFYTVKCNSAPA VLEILAALGTGFACSSKNEMALVQE LGVPPENIIYISPCKQVSQIKYAAK VGVNILTCDNEIELKKIARNHPNAK VLLHIATEDNIGGEEGNMKFGTTLK NCRHLLECAKELDVQIIGVKFHVSS ACKESQVYVHALSDARCVFDMAGEI GFTMNMLDIGGGFTGTEFQLEEVNH VISPLLDIYFPEGSGVKIISEPGSY YVSSAFTLAVNIIAKKVVENDKFPS GVEKTGSDEPAFMYYMNDGVYGSFA SKLSEDLNTIPEVHKKYKEDEPLFT SSLWGPSCDELDQIVESCLLPELNV GDWLIFDNMGADSFHEPSAFNDFQR PAIYYMMSFSDWYEMQDAGITSDSM MKNFFFVPSCIQLSQEDSFSAEADI EGRMDPKSCDKTHTCPPCPAPEAEG APSVFLFPPKPKDTLMISRTPEVTC VVVDVSHEDPEVKFNWYVDGVEVHN AKTKPREEQYNSTYRVVSVLTVLHQ DWLNGKEYKCKVSNKALPAPIEKTI SKAKGQPREPQVYTLPPSRDELTKN QVSLTCLVKGFYPSDIAVEWESNGQ PENNYKATPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHY TQKSLSLSPGKGLNDIFEAQKIEWH E
• Purity: > 90 % by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.31 mg/mL
• Storage Buffer: Sterile 20mM Tris, 300mM NaCl, 0.5 % SKL

Gene Information

• Gene Name: AZIN1 antizyme inhibitor 1 [ Homo sapiens (human) ]
• Official Symbol: AZIN1
• Synonyms: AZIN1; antizyme inhibitor 1; OAZIN, ornithine decarboxylase antizyme inhibitor; OAZI; ODC1L; ornithine decarboxylase 1 like; AZI; ornithine decarboxylase antizyme inhibitor; OAZIN; MGC691; MGC3832
• Gene ID: 51582
• mRNA Refseq: NM_015878
• Protein Refseq: NP_056962
• MIM: 607909
• UniProt ID: O14977