| Description : |
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
80.4 kDa |
| AA Sequence : |
MNKGWLELESDPGLFTLLVEDFGVK GVQVEEIYDLQSKCQGPVYGFIFLF KWIEERRSRRKVSTLVDDTSVIDDD IVNNMFFAHQLIPNSCATHALLSVL LNCSSVDLGPTLSRMKDFTKGFSPE SKGYAIGNAPELAKAHNSHARPEPR HLPEKQNGLSAVRTMEAFHFVSYVP ITGRLFELDGLKVYPIDHGPWGEDE EWTDKARRVIMERIGLATAGEPYHD IRFNLMAVVPDRRIKYEARLHVLKV NRQTVLEALQQLIRVTQPELIQTHK SQESQLPEESKSASNKSPLVLEANR APAASEGNHTDGAEEAAGSCAQAPS HSPPNKPKLVVKPPGSSLNGVHPNP TPIVQRLPAFLDNHNYAKSPMQEEE DLAAGVGRSRVPVRPPQQYSDDEDD YEDDEEDDVQNTNSALRYKGKGTGK PGALSGSADGQLSVLQPNTINVLAE KLKESQKDLSIPLSIKTSSGAGSPA VAVPTHSQPSPTPSNESTDTASEIG SAFNSPLRSPIRSANPTRPSSPVTS HISKVLFGEDDSLLRVDCIRYNRAV RDLGPVISTGLLHLAEDGVLSPLAL TEGGKGSSPSIRPIQGSQGSSSPVE KEVVEATDSREKTGMVRPGEPLSGE KYSPKELLALLKCVEAEIANYEACL KEEVEKRKKFKIDDQRRTHNYDEFI CTFISMLAQEGMLANLVEQNISVRR RQGVSIGRLHKQRKPDRRKRSRPYK AKRQTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
