| Description : |
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
92.6 kDa |
| AA Sequence : |
MAAGKFASLPRNMPVNHQFPLASSM DLLSSRSPLAEHRPDAYQDVSIHGT LPRKKKGPPPIRSCDDFSHMGTLPH SKSPRQNSPVTQDGIQESPWQDRHG ETFTFRDPHLLDPTVEYVKFSKERH IMDRTPEKLKKELEEELLLSSEDLR SHAWYHGRIPRQVSENLVQRDGDFL VRDSLSSPGNFVLTCQWKNLAQHFK INRTVLRLSEAYSRVQYQFEMESFD SIPGLVRCYVGNRRPISQQSGAIIF QPINRTVPLRCLEEHYGTSPGQARE GSLTKGRPDVAKRLSLTMGGVQARE QNLPRGNLLRNKEKSGSQPACLDHM QDRRALSLKAHQSESYLPIGCKLPP QSSGVDTSPCPNSPVFRTGSEPALS PAVVRRVSSDARAGEALRGSDSQLC PKPPPKPCKVPFLKVPSSPSAWLNS EANYCELNPAFATGCGRGAKLPSCA QGSHTELLTAKQNEAPGPRNSGVNY LILDDDDRERPWEPAAAQMEKGQWD KGEFVTPLLETVSSFRPNEFESKFL PPENKPLETAMLKRAKELFTNNDPK VIAQHVLSMDCRVARILGVSEEMRR NMGVSSGLELITLPHGHQLRLDIIE RHNTMAIGIAVDILGCTGTLEDRAA TLSKIIQVAVELKDSMGDLYSFSAL MKALEMPQITRLEKTWTALRHQYTQ TAILYEKQLKPFSKLLHEGRESTCV PPNNVSVPLLMPLVTLMERQAVTFE GTDMWEKNDQSCEIMLNHLATARFM AEAADSYRMNAERILAGFQPDEEMN EICKTEFQMRLLWGSKGAQVNQTER YEKFNQILTALSRKLEPPPVKQAEL TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
