Recombinant Human BFSP1, His-tagged

• Cat.No.: BFSP1-10217H
• Product Overview: Recombinant Human BFSP1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: C-term-350a.a.
• Description: More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, CP49 (also known as phakinin) and the protein product of this gene, filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Multiple transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: BFSP1 beaded filament structural protein 1, filensin [ Homo sapiens ]
• Official Symbol: BFSP1
• Synonyms: BFSP1; beaded filament structural protein 1, filensin; filensin; CP94; CP115; LIFL H; cytoskeletal protein, 115 KD; lens intermediate filament-like heavy; lens fiber cell beaded-filament structural protein CP 115; LIFL-H
• Gene ID: 631
• mRNA Refseq: NM_001161705
• Protein Refseq: NP_001155177
• MIM: 603307
• UniProt ID: Q12934
• Chromosome Location: 20p12.1
• Function: structural constituent of cytoskeleton; structural constituent of eye lens