Recombinant Human BRDT, His-tagged

• Cat.No.: BRDT-1912H
• Product Overview: Recombinant protein includes Bromo 1 domain (257-382 aa) with N-terminal His-tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 257-382 aa
• Description: BrdT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence. The bromodomain is found in proteins that regulate transcription. BrdT drives a meiotic and post-meiotic gene expression program. It also controls the genome-wide post-meiotic genome reorganization that occurs after histone hyperacetylation in elongating spermatids. It may play a role in the transcriptional regulation of spermatogenesis. It also seems to have a structural ATP-independent role in the reorganization of acetylated chromatin.
• Appearance: Liquid
• Form: rh-BrdT is supplied as a solution in 50 mM Tris, pH 8.0, 150 mM NaCl and 10% Glycerol.
• Molecular Mass: 14.9 kDa (126 aa, 257-382 aa + NT His Tag)
• Purity: ≥98% by SDS-PAGE
• Usage: For Research Use Only! Not For Use in Humans.
• Storage: Stable for 1 year at –80°C. Avoid multiple freeze/thaw cycles as activity may decrease.

Gene Information

• Gene Name: BRDT bromodomain, testis-specific [ Homo sapiens (human) ]
• Official Symbol: BRDT
• Synonyms: BRDT; bromodomain, testis-specific; CT9; BRD6; bromodomain testis-specific protein; RING3-like protein; cancer/testis antigen 9
• Gene ID: 676
• mRNA Refseq: NM_001726
• Protein Refseq: NP_001717
• MIM: 602144
• UniProt ID: Q58F21
• Chromosome Location: 1p22.1
• Function: histone acetyl-lysine binding; histone binding; transcription coactivator activity