Recombinant Human CADPS2 Protein, MYC/DDK-tagged

• Cat.No.: CADPS2-2293H
• Product Overview: Recombinant human CADPS2 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Description: This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 147.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CADPS2 Ca++-dependent secretion activator 2 [ Homo sapiens ]
• Official Symbol: CADPS2
• Synonyms: FLJ40851; KIAA1591
• Gene ID: 93664
• mRNA Refseq: NM_001009571
• Protein Refseq: NP_001009571
• MIM: 609978
• UniProt ID: Q86UW7

Reviews

01/07/2022

The product is vital for our success.

01/11/2019

Quick availability reduces experiment downtime.

08/19/2018

Precise concentrations ensure accurate results.

Q&As

What are the specific binding partners of CADPS2 in the presynaptic terminal?

CADPS2 interacts with various presynaptic proteins, including Munc13, RIM, and voltage-gated calcium channels. These interactions are critical for its role in synaptic vesicle exocytosis.

How does CADPS2 participate in the regulation of synaptic vesicle recycling?

CADPS2 is involved in the replenishment of the readily releasable pool of synaptic vesicles, ensuring efficient neurotransmitter release during sustained neuronal activity.

What is the role of CADPS2 in long-term potentiation (LTP) and synaptic plasticity?

CADPS2 contributes to the regulation of LTP, a cellular mechanism underlying learning and memory, by modulating neurotransmitter release and synaptic strength.

How is CADPS2 different from other synaptic vesicle proteins, such as synaptophysin or synaptobrevin?

CADPS2 is distinct from synaptophysin and synaptobrevin because it specifically functions in the regulation of synaptic vesicle exocytosis, whereas synaptophysin and synaptobrevin are involved in vesicle trafficking and fusion.

How does CADPS2 contribute to the regulation of neurotransmitter release?

CADPS2 helps in the priming of synaptic vesicles by binding to calcium ions and facilitating the assembly of the SNARE complex, which is essential for vesicle fusion and neurotransmitter release.