Recombinant Human CAMKK2, GST-tagged, Active

• Cat.No.: CAMKK2-270H
• Product Overview: Recombinant full-length human CAMKK2 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 88 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: CAMKK2 (CAMKKβ) is a member of the CAMKK family. It is broadly distributed in tissues with highest levels in brain, thymus, spleen, and testis. CaMKK2 undergoes intramolecular autophosphorylation, is regulated by Ca2+/calmodulin and phosphorylates CaMKI and CaMKIV on Thr177 and Thr200, respectively. CaMKK2 activates both CaMKI and CaMKIV when coexpressed in Jurkat T cells. CaMKK2 also phosphorylates and regulates the activity of AMPK, which is an important regulator of cellular metabolism in response to metabolic stress.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta [ Homo sapiens ]
• Synonyms: CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2, beta; CAMKK; CAMKKB; KIAA0787; MGC15254; calcium/calmodulin-dependent protein kinase kinase 2 beta; CAMKK beta protein; calcium/calmodulin-dependent protein kinase beta; EC 2.7.11.17; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta; Calcium/calmodulin-dependent protein kinase kinase beta
• Gene ID: 10645
• mRNA Refseq: NM_006549
• Protein Refseq: NP_006540
• UniProt ID: Q96RR4
• Chromosome Location: 12q24.2
• Pathway: Adipocytokine signaling pathway
• Function: ATP binding; calcium ion binding; calmodulin binding; calmodulin-dependent protein kinase activity; nucleotide binding; protein tyrosine kinase activity; transferase activity