Recombinant Human CAP2, His-tagged

• Cat.No.: CAP2-10697H
• Product Overview: Recombinant Human CAP2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 129-477a.a.
• Description: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) [ Homo sapiens ]
• Official Symbol: CAP2
• Synonyms: CAP2; CAP, adenylate cyclase-associated protein, 2 (yeast); adenylyl cyclase-associated protein 2; CAP 2; 2810452G09Rik
• Gene ID: 10486
• mRNA Refseq: NM_006366
• Protein Refseq: NP_006357
• UniProt ID: P40123
• Chromosome Location: 6p22.3
• Pathway: Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Role of Abl in Robo-Slit signaling, organism-specific biosystem; Signaling by Robo receptor, organism-specific biosystem
• Function: actin binding; binding