Recombinant Human CAPN6 Protein, GST-Tagged CAPN6-0368H

Recombinant Human CAPN6 Protein, GST-Tagged

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Recombinant Human CAPN6 Protein, GST-Tagged

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Cat.No. : CAPN6-0368H
Product Overview : Human CAPN6 full-length ORF (BAG35579.1, 1 a.a. - 641 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 101 kDa
AA Sequence : MGPPLKLFKNQKYQE LKQECIKDSRLFCDP TFLPENDSLFYNRLL PGKVVWKRPQDICDD PHLIVGNISNHQLTQ GRLGHKPMVSAFSCL AVQESHWTKTIPNHK EQEWDPQKTEKYAGI FHFRFWHFGEWTEVV IDDLLPTINGDLVFS FSTSMNEFWNALLEK AYAKLLGCYEALDGL TITDIIVDFTGTLAE TVDMQKGRYTELVEE KYKLFGELYKTFTKG GLICCSIESPNQEEQ EVETDWGLLKGHTYT MTDIRKIRLGERLVE VFSAEKVYMVRLRNP LGRQEWSGPWSEISE EWQQLTASDRKNLGL VMSDDGEFWMSLEDF CRNFHKLNVCRNVNN PIFGRKELESVLGCW TVDDDPLMNRSGGCY NNRDTFLQNPQYIFT VPEDGHKVIMSLQQK DLRTYRRMGRPDNYI IGFELFKVEMNRKFR LHHLYIQERAGTSTY IDTRTVFLSKYLKKG NYVLVPTMFQHGRTS EFLLRIFSEVPVQLR ELTLDMPKMSCWNLA RGYLKVVTQITVHSA EDLEKKYANETVNPY LVIKCGKEEVRSPVQ KNTVHAIFDTQAIFY RRTTDIPIIVQVWNS RKFCDQFLGQVTLDA DPSDCRDLKSLYLRK KGGPTAKVKQGHISF KVISSDDLTEL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CAPN6 calpain 6 [ Homo sapiens ]
Official Symbol : CAPN6
Synonyms : CALP M; Calpain-6; Calpain-like protease X-linked; Calpamodulin; CALPM; CAN6_HUMAN; CANP X; CANPX; CAPN 6; CAPN6
Gene ID : 827
mRNA Refseq : NM_014289
Protein Refseq : NP_055104
MIM : 300146
UniProt ID : Q9Y6Q1

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