Recombinant Human CAPN6 Protein, GST-Tagged

• Cat.No.: CAPN6-0368H
• Product Overview: Human CAPN6 full-length ORF (BAG35579.1, 1 a.a. - 641 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 101 kDa
• AA Sequence: MGPPLKLFKNQKYQELKQECIKDSR LFCDPTFLPENDSLFYNRLLPGKVV WKRPQDICDDPHLIVGNISNHQLTQ GRLGHKPMVSAFSCLAVQESHWTKT IPNHKEQEWDPQKTEKYAGIFHFRF WHFGEWTEVVIDDLLPTINGDLVFS FSTSMNEFWNALLEKAYAKLLGCYE ALDGLTITDIIVDFTGTLAETVDMQ KGRYTELVEEKYKLFGELYKTFTKG GLICCSIESPNQEEQEVETDWGLLK GHTYTMTDIRKIRLGERLVEVFSAE KVYMVRLRNPLGRQEWSGPWSEISE EWQQLTASDRKNLGLVMSDDGEFWM SLEDFCRNFHKLNVCRNVNNPIFGR KELESVLGCWTVDDDPLMNRSGGCY NNRDTFLQNPQYIFTVPEDGHKVIM SLQQKDLRTYRRMGRPDNYIIGFEL FKVEMNRKFRLHHLYIQERAGTSTY IDTRTVFLSKYLKKGNYVLVPTMFQ HGRTSEFLLRIFSEVPVQLRELTLD MPKMSCWNLARGYLKVVTQITVHSA EDLEKKYANETVNPYLVIKCGKEEV RSPVQKNTVHAIFDTQAIFYRRTTD IPIIVQVWNSRKFCDQFLGQVTLDA DPSDCRDLKSLYLRKKGGPTAKVKQ GHISFKVISSDDLTEL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CAPN6 calpain 6 [ Homo sapiens ]
• Official Symbol: CAPN6
• Synonyms: CALP M; Calpain-6; Calpain-like protease X-linked; Calpamodulin; CALPM; CAN6_HUMAN; CANP X; CANPX; CAPN 6; CAPN6
• Gene ID: 827
• mRNA Refseq: NM_014289
• Protein Refseq: NP_055104
• MIM: 300146
• UniProt ID: Q9Y6Q1