Recombinant Human CAPN7 Protein, MYC/DDK-tagged

• Cat.No.: CAPN7-32H
• Product Overview: Recombinant Human CAPN7 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 92.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CAPN7 calpain 7 [ Homo sapiens ]
• Official Symbol: CAPN7
• Synonyms: PALBH; CALPAIN7; calpain like protease; homolog of Aspergillus Nidulans PALB; palB homolog
• Gene ID: 23473
• mRNA Refseq: NM_014296
• Protein Refseq: NP_055111
• MIM: 606400
• UniProt ID: Q9Y6W3