Recombinant Human Catenin, Beta Interacting Protein 1, His-tagged

• Cat.No.: CTNNBIP1-2585H
• Product Overview: Recombinant human CTNNBIP1, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: CTNNBIP1 binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. This protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene.
• Sequences: MGSSHHHHHH SSGLVPRGSH MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q.
• Molecular Weight: 11.3kDa (101a) confirmed by MALDI-TOF.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 2mM DTT, 100mM NaCl.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CTNNBIP1 catenin, beta interacting protein 1 [ Homo sapiens ]
• Synonyms:
  CTNNBIP1; catenin, beta interacting protein 1; OTTHUMP00000001722; beta-catenin-interacting protein 1; beta-catenin-interacting protein ICAT; catenin, beta-interacting protein 1; inhibitor of beta-catenin and Tcf-4; RP11-84A14.1; ICAT; MGC15093
• Gene ID: 56998
• mRNA Refseq: NM_001012329
• Protein Refseq: NP_001012329
• MIM: 607758
• UniProt ID: Q9NSA3
• Chromosome Location: 1p36.22
• Pathway: Wnt signaling pathway
• Function: beta-catenin binding; otein binding