Recombinant Human CBFB Protein (M1-P182), His tagged
Cat.No. : | CBFB-0484H |
Product Overview : | Recombinant Human 6His-strepII-TEV-GG-CBFB(M1-P182 end) Protein was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid |
Protein Length : | M1-P182 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | CBFB core-binding factor, beta subunit [ Homo sapiens (human) ] |
Official Symbol : | CBFB |
Synonyms : | CBFB; core-binding factor, beta subunit; core-binding factor subunit beta; PEBP2B; CBF-beta; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit; polyomavirus enhancer-binding protein 2 beta subunit; polyomavirus enhancer binding protein 2, beta subunit; |
Gene ID : | 865 |
mRNA Refseq : | NM_001755 |
Protein Refseq : | NP_001746 |
MIM : | 121360 |
UniProt ID : | Q13951 |
Products Types
◆ Recombinant Protein | ||
CBFB-465R | Recombinant Rhesus Macaque CBFB Protein, His (Fc)-Avi-tagged | +Inquiry |
Cbfb-787M | Recombinant Mouse Cbfb Protein, MYC/DDK-tagged | +Inquiry |
CBFB-1262M | Recombinant Mouse CBFB Protein, His (Fc)-Avi-tagged | +Inquiry |
Cbfb-590M | Recombinant Mouse Cbfb Protein, His-tagged | +Inquiry |
CBFB-0483H | Recombinant Human CBFB Protein (M1-P182), Tag Free | +Inquiry |
◆ Lysates | ||
CBFB-7815HCL | Recombinant Human CBFB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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