Recombinant Human CCM2 Protein, GST-Tagged
Cat.No. : | CCM2-0645H |
Product Overview : | Human CCM2 full-length ORF (NP_113631.1, 1 a.a. - 444 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 75.2 kDa |
AA Sequence : | MEEEGKKGKKPGIVSPFKRVFLKGE KSRDKKAHEKVTERRPLHTVVLSLP ERVEPDRLLSDYIEKEVKYLGQLTS IPGYLNPSSRTEILHFIDNAKRAHQ LPGHLTQEHDAVLSLSAYNVKLAWR DGEDIILRVPIHDIAAVSYVRDDAA HLVVLKTAQDPGISPSQSLCAESSR GLSAGSLSESAVGPVEACCLVILAA ESKVAAEELCCLLGQVFQVVYTEST IDFLDRAIFDGASTPTHHLSLHSDD SSTKVDIKETYEVEASTFCFPESVD VGGASPHSKTISESELSASATELLQ DYMLTLRTKLSSQEIQQFAALLHEY RNGASIHEFCINLRQLYGDSRKFLL LGLRPFIPEKDSQHFENFLETIGVK DGRGIITDSFGRHRRALSTTSSSTT NGNRATGSSDDRSAPSEGDEWDRMI SDISSDIEALGCSMDQDSA |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CCM2 cerebral cavernous malformation 2 [ Homo sapiens ] |
Official Symbol : | CCM2 |
Synonyms : | CCM2; cerebral cavernous malformation 2; MGC4067; |
Gene ID : | 83605 |
mRNA Refseq : | NM_031443 |
Protein Refseq : | NP_113631 |
MIM : | 607929 |
UniProt ID : | Q9BSQ5 |
Products Types
◆ Recombinant Protein | ||
Ccm2-2045M | Recombinant Mouse Ccm2 Protein, Myc/DDK-tagged | +Inquiry |
CCM2-523R | Recombinant Rhesus Macaque CCM2 Protein, His (Fc)-Avi-tagged | +Inquiry |
CCM2-464Z | Recombinant Zebrafish CCM2 | +Inquiry |
CCM2-4167C | Recombinant Chicken CCM2 | +Inquiry |
CCM2-695R | Recombinant Rhesus monkey CCM2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CCM2-7719HCL | Recombinant Human CCM2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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