Recombinant Human CD200 Protein, MYC/DDK-tagged

• Cat.No.: CD200-0743H
• Product Overview: Recombinant protein of Homo sapiens CD200 molecule (CD200), transcript variant 2 with MYC/DDK tag at C-terminal was expressed in HEK293T.

Specification

• Description: This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 32.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at –80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: CD200
• Official Symbol: CD200 CD200 molecule [ Homo sapiens (human) ]
• Synonyms: CD200; CD200 molecule; MRC; MOX1; MOX2; OX-2; OX-2 membrane glycoprotein; CD200 antigen; antigen identified by monoclonal antibody MRC OX-2
• Gene ID: 4345
• mRNA Refseq: NM_001004196
• Protein Refseq: NP_001004196
• MIM: 155970
• UniProt ID: P41217

Reviews

08/01/2022

Swift protein sequencing, helps identify unknown proteins.

05/04/2022

Great protein crystallization services, key for structural biology.

05/02/2019

Invaluable protein-protein interaction assays, integral for research.

Q&As

How does CD200 contribute to the regulation of bone marrow and hematopoietic stem cell niches?

CD200 regulates bone marrow and hematopoietic environments, supporting stem cell maintenance and differentiation.

How does CD200 influence tumor immune evasion and the tumor microenvironment in cancer?

CD200 contributes to immune evasion in cancers, affecting tumor progression and response to immunotherapy.

What role does CD200 play in the suppression of inflammatory responses in autoimmune diseases?

CD200 plays a role in suppressing inflammatory responses, which is crucial in autoimmune disease management.

What are the effects of CD200 dysregulation on tissue graft rejection and transplant tolerance?

Dysregulation of CD200 affects tissue graft rejection, influencing transplant tolerance and success.

How do alterations in CD200 expression impact the aging process and age-related immune changes?

Changes in CD200 expression impact the aging immune system, affecting age-related immune regulation and function.

What is the impact of CD200 expression on neuroinflammatory processes and neurodegenerative diseases?

CD200 expression influences neuroinflammatory processes, potentially impacting neurodegenerative diseases.

How does CD200 interact with its receptor CD200R, and what are the implications for immune regulation?

CD200 interacts with CD200R to modulate immune responses, promoting immune tolerance and reducing inflammation.