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Recombinant Human CD24 protein, His-tagged

Cat.No. : CD24-475H
Product Overview : Recombinant CD24 protein (Ser27-Gly59), fused to His-tag at C-terminus, was expressed in human 293 cells (HEK293).
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Description : CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 μm filtered solution in PBS with Arginine, pH7.4. Normally trehalose is added as protectant before lyophilization.
Molecular Mass : 5.0 kDa
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
4-8 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Protein length : Ser27-Gly59
Gene Name : CD24
Official Symbol : CD24
Synonyms : CD24A
Gene ID : 100133941
mRNA Refseq : NM_013230.3
Protein Refseq : NP_037362.1
MIM : 600074
UniProt ID : P25063

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
10/31/2022

    The technician guided me through the process, which led to satisfactory results.

    10/18/2022

      Prompt delivery helped me get satisfactory experimental results in a short period of time.

      07/18/2021

        The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.

        Q&As (7)

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        What are the effects of overexpressing CD24? 01/30/2023

        Overexpression of CD24 increases the proliferation, migration and invasion of breast cancer cells.

        What diseases is CD24 relevant to the study of? 08/16/2022

        CD24 has been closely associated with the study of diseases such as oral squamous cell carcinoma, breast cancer and gastric cancer.

        How do CD24 expression levels change in breast cancer tissues? 07/21/2022

        CD24 expression was higher in breast cancer tissues compared to normal breast tissues.

        Where is CD24 primarily expressed? 04/01/2022

        CD24 is expressed on the surface of different cell types, including myeloid cells, keratinocytes, and macrophages.

        What are the effects of blocking the expression of CD24? 02/04/2022

        Tumor growth was retarded after blocking CD24 expression.

        What biological processes is CD24 involved in? 11/04/2021

        CD24 regulates tumor cell growth and proliferation, metastasis and invasion by participating in relevant signal transduction pathways that mediate tumorigenesis and development.

        How is CD24 related to the inhibitory receptor Siglec-10? 03/11/2021

        CD24 binds to the inhibitory receptor Siglec-10.

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