Recombinant Human CD24 protein, His-tagged
Cat.No. : | CD24-475H |
Product Overview : | Recombinant CD24 protein (Ser27-Gly59), fused to His-tag at C-terminus, was expressed in human 293 cells (HEK293). |
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Description : | CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from 0.22 μm filtered solution in PBS with Arginine, pH7.4. Normally trehalose is added as protectant before lyophilization. |
Molecular Mass : | 5.0 kDa |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: 4-8 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Protein length : | Ser27-Gly59 |
Gene Name : | CD24 |
Official Symbol : | CD24 |
Synonyms : | CD24A |
Gene ID : | 100133941 |
mRNA Refseq : | NM_013230.3 |
Protein Refseq : | NP_037362.1 |
MIM : | 600074 |
UniProt ID : | P25063 |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe technician guided me through the process, which led to satisfactory results.
Prompt delivery helped me get satisfactory experimental results in a short period of time.
The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.
Q&As (7)
Ask a questionOverexpression of CD24 increases the proliferation, migration and invasion of breast cancer cells.
CD24 has been closely associated with the study of diseases such as oral squamous cell carcinoma, breast cancer and gastric cancer.
CD24 expression was higher in breast cancer tissues compared to normal breast tissues.
CD24 is expressed on the surface of different cell types, including myeloid cells, keratinocytes, and macrophages.
Tumor growth was retarded after blocking CD24 expression.
CD24 regulates tumor cell growth and proliferation, metastasis and invasion by participating in relevant signal transduction pathways that mediate tumorigenesis and development.
CD24 binds to the inhibitory receptor Siglec-10.
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