Recombinant Human CD96 Protein, T7-His-TEV-tagged

• Cat.No.: CD96-25H
• Product Overview: Full-length extracellular domain of human CD96 cDNA (22 – 519aa) was constructed with codon optimization gene synthesis and expressed with a human N-terminal T7-His-TEV cleavage site Tag (29aa) fusion. This protein was expressed in E. coli as inclusion bodies. The final product was refolded and chromatographically purified.

Specification

• Description: The protein encoded by human T-cell surface protein tactile (CD96) gene is a receptor, which may be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. It promotes NK cell-target adhesion by interacting with PVR present on target cells. CD96 may function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
• Source: E. coli
• Species: Human
• Tag: T7-His
• Form: Liquid
• AA Sequence: MASMTGGQQMGRGHHHHHHENLYFQ GGEFVWEKTVNTEENVYATLGSDVN LTCQTQTVGFFVQMQWSKVTNKIDL IAVYHPQYGFYCAYGRPCESLVTFT ETPENGSKWTLHLRNMSCSVSGRYE CMLVLYPEGIQTKIYNLLIQTHVTA DEWNSNHTIEIEINQTLEIPCFQNS SSKISSEFTYAWSVENSSTDSWVLL SKGIKEDNGTQETLISQNHLISNST LLKDRVKLGTDYRLHLSPVQIFDDG RKFSCHIRVGPNKILRSSTTVKVFA KPEIPVIVENNSTDVLVERRFTCLL KNVFPKANITWFIDGSFLHDEKEGI YITNEERKGKDGFLELKSVLTRVHS NKPAQSDNLTIWCMALSPVPGNKVW NISSEKITFLLGSEISSTDPPLSVT ESTLDTQPSPASSVSPARYPATSSV TLVDVSALRPNTTPQPSNSSMTTRG FNYPWTSSGTDTKKSVSRIPSETYS SSPSGAGSTLHDNVFTSTARAFSEV PTTANGSTKTNHVHITGIVVNKPKD GM
• Purity: > 90% by SDS-PAGE.
• Storage: Keep at -80 centigrade for long term storage. Product is stable at 4 centigrade for at least 30 days.
• Concentration: 0.2 mg/mL
• Storage Buffer: Sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.

Gene Information

• Gene Name: CD96
• Official Symbol: CD96 CD96 molecule [ Homo sapiens (human) ]
• Synonyms: CD96; CD96 molecule; TACTILE; T-cell surface protein tactile; T cell activation, increased late expression; cell surface antigen CD96; t cell-activated increased late expression protein
• Gene ID: 10225
• mRNA Refseq: NM_005816
• Protein Refseq: NP_005807
• MIM: 606037
• UniProt ID: P40200