| Species : |
Human |
| Source : |
HEK293 |
| Tag : |
His |
| Protein Length : |
54-617 aa |
| Description : |
Cadherin-11 is a type II cadherin which mediates cell-to-cell homophilic interactions. Cadherin-11 is mainly expressed on mesenchymal cells and is essential for tissue migration and organization during embryogenesis, while its expression on epithelial cancer cells is implicated in tumor progression and metastasis suggesting a potential role in the epithelial-to-mesenchymal transition phenomenon. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. In addition, cadherin-11 has been shown to increase the invasive capacity of Fibroblast-like Synoviocytes (FLS) and consequently be involved in the formation of the rheumatoid pannus. |
| Form : |
Lyophilized from 0.22 μm filtered solution in PBS, 0.5 M Arginine, pH7.4 with trehalose as protectant. |
| Molecular Mass : |
The protein has a calculated MW of 63.8 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin : |
Less than 1.0 EU/μg by the LAL method/rFC method. |
| Purity : |
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS. |
| Storage : |
This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. |
| Reconstitution : |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
