Recombinant Human CDK4 Protein, MYC/DDK-tagged

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Recombinant Human CDK4 Protein, MYC/DDK-tagged

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Cat.No. : CDK4-3139H
Product Overview : Recombinant Human CDK4 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
Description : The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 33.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CDK4 cyclin-dependent kinase 4 [ Homo sapiens ]
Official Symbol : CDK4
Synonyms : CMM3; PSK-J3
Gene ID : 1019
mRNA Refseq : NM_000075
Protein Refseq : NP_000066
MIM : 123829
UniProt ID : P11802

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