Cat.No.:	CES2-22H
Product Overview:	Recombinant human CES2 protein (Gln27-Leu559) with a C-terminal 10-His tag was expressed in mouse myeloma cell line.
Description:	This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.
Source:	NS0
Species:	Human
Tag :	His
Bio-activity:	Measured by its ability to hydrolyze p-nitrophenylacetate. The specific activity is >30,000 pmol/min/μg, measured under the described conditions.
Molecular Mass:	60 kDa
N-terminal Sequence Analysis:	Gln27 predicted
Endotoxin:	<1.0 EU per 1 μg of the protein by the LAL method.
Purity:	>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 centigrade as supplied. 3 months, -70 centigrade under sterile conditions after opening.
Storage Buffer:	Supplied as a 0.2 μm filtered solution in Sodium Acetate, NaCl and Glycerol.

Gene Name:	CES2
Official Symbol:	CES2 carboxylesterase 2 [ Homo sapiens (human) ]
Synonyms:	Carboxylesterase 2; CE-2; CES2; PCE-2; carboxylesterase 2; iCE; CES2A1; cocaine esterase; carboxylesterase 2 (intestine, liver); hCE-2; intestinal carboxylesterase; liver carboxylesterase-2; methylumbelliferyl-acetate deacetylase 2; EC 3.1.1.1; EC 3.1.1.56; EC 3.1.1.84
Gene ID:	8824
mRNA Refseq:	NM_003869
Protein Refseq:	NP_003860
MIM:	605278
UniProt ID:	O00748

Online Inquiry