| Description : |
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Form : |
Lyophilized |
| Molecular Mass : |
51.3 kDa |
| Protein Length : |
466 |
| AA Sequence : |
MVRSVAWAGFMVLLMIPWGSAAKLV CYFTNWAQYRQGEARFLPKDLDPSL CTHLIYAFAGMTNHQLSTTEWNDET LYQEFNGLKKMNPKLKTLLAIGGWN FGTQKFTDMVATANNRQTFVNSAIR FLRKYSFDGLDLDWEYPGSQGSPAV DKERFTTLVQDLANAFQQEAQTSGK ERLLLSAAVPAGQTYVDAGYEVDKI AQNLDFVNLMAYDFHGSWEKVTGHN SPLYKRQEESGAAASLNVDAAVQQW LQKGTPASKLILGMPTYGRSFTLAS SSDTRVGAPATGSGTPGPFTKEGGM LAYYEVCSWKGATKQRIQDQKVPYI FRDNQWVGFDDVESFKTKVSYLKQK GLGGAMVWALDLDDFAGFSCNQGRY PLIQTLRQELSLPYLPSGTPELEVP KPGQPSEPEHGPSPGQDTFCQGKAD GLYPNPRERSSFYSCAAGRLFQQSC PTGLVFSNSCKCCTWN |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
