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Recombinant Human CKMT1B Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CKMT1B-2713H
Product Overview : CKMT1B MS Standard C13 and N15-labeled recombinant protein (NP_066270) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 47 kDa
AA Sequence : MAGPFSRLLSARPGLRLLALAGAGS LAAGFLLRPEPVRAASERRRLYPPS AEYPDLRKHNNCMASHLTPAVYARL CDKTTPTGWTLDQCIQTGVDNPGHP FIKTVGMVAGDEETYEVFADLFDPV IQERHNGYDPRTMKHTTDLDASKIR SGYFDERYVLSSRVRTGRSIRGLSL PPACTRAERREVERVVVDALSGLKG DLAGRYYRLSEMTEAEQQQLIDDHF LFDKPVSPLLTAAGMARDWPDARGI WHNNEKSFLIWVNEEDHTRVISMEK GGNMKRVFERFCRGLKEVERLIQER GWEFMWNERLGYILTCPSNLGTGLR AGVHIKLPLLSKDSRFPKILENLRL QKRGTGGVDTAATGGVFDISNLDRL GKSEVELVQLVIDGVNYLIDCERRL ERGQDIRIPTPVIHTKHTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CKMT1B creatine kinase, mitochondrial 1B [ Homo sapiens (human) ]
Official Symbol : CKMT1B
Synonyms : CKMT1B; creatine kinase, mitochondrial 1B; CKMT, CKMT1, creatine kinase, mitochondrial 1 (ubiquitous); creatine kinase U-type, mitochondrial; UMTCK; U-MtCK; mia-CK; ubiquitous mitochondrial creatine kinase; acidic-type mitochondrial creatine kinase; creatine kinase, mitochondrial 1 (ubiquitous); CKMT; CKMT1; CKMT1A;
Gene ID : 1159
mRNA Refseq : NM_020990
Protein Refseq : NP_066270
MIM : 123290
UniProt ID : P12532

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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