Recombinant Human CLCN5 Protein, GST-tagged

• Cat.No.: CLCN5-1418H
• Product Overview: Human CLCN5 full-length ORF ( NP_000075.1, 1 a.a. - 746 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 109.5 kDa
• AA Sequence: MDFLEEPIPGVGTYDDFNTIDWVRE KSRDRDRHREITNKSKESTWALIHS VSDAFSGWLLMLLIGLLSGSLAGLI DISAHWMTDLKEGICTGGFWFNHEH CCWNSEHVTFEERDKCPEWNSWSQL IISTDEGAFAYIVNYFMYVLWALLF AFLAVSLVKVFAPYACGSGIPEIKT ILSGFIIRGYLGKWTLVIKTITLVL AVSSGLSLGKEGPLVHVACCCGNIL CHCFNKYRKNEAKRREVLSAAAAAG VSVAFGAPIGGVLFSLEEVSYYFPL KTLWRSFFAALVAAFTLRSINPFGN SRLVLFYVEFHTPWHLFELVPFILL GIFGGLWGALFIRTNIAWCRKRKTT QLGKYPVIEVLVVTAITAILAFPNE YTRMSTSELISELFNDCGLLDSSKL CDYENRFNTSKGGELPDRPAGVGVY SAMWQLALTLILKIVITIFTFGMKI PSGLFIPSMAVGAIAGRLLGVGMEQ LAYYHQEWTVFNSWCSQGADCITPG LYAMVGAAACLGGVTRMTVSLVVIM FELTGGLEYIVPLMAAAMTSKWVAD ALGREGIYDAHIRLNGYPFLEAKEE FAHKTLAMDVMKPRRNDPLLTVLTQ DSMTVEDVETIISETTYSGFPVVVS RESQRLVGFVLRRDLIISIENARKK QDGVVSTSIIYFTEHSPPLPPYTPP TLKLRNILDLSPFTVTDLTPMEIVV DIFRKLGLRQCLVTHNGRLLGIITK KDVLKHIAQMANQDPDSILFN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CLCN5 chloride channel, voltage-sensitive 5 [ Homo sapiens ]
• Official Symbol: CLCN5
• Synonyms: CLCN5; chloride channel, voltage-sensitive 5; chloride channel 5 , nephrolithiasis 1 (X linked) , nephrolithiasis 2, X linked , NPHL1, NPHL2; H(+)/Cl(-) exchange transporter 5; ClC 5; CLC5; Dent disease; DENTS; hCIC K2; hClC K2; XLRH; XRN; chloride channel 5; chloride channel protein 5; chloride transporter ClC-5; CLCK2; NPHL1; NPHL2; clC-5; hCIC-K2; hClC-K2
• Gene ID: 1184
• mRNA Refseq: NM_000084
• Protein Refseq: NP_000075
• MIM: 300008
• UniProt ID: P51795