Recombinant Human CLDN11 Protein, GST-tagged CLDN11-1427H

Recombinant Human CLDN11 Protein, GST-tagged

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Recombinant Human CLDN11 Protein, GST-tagged

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Cat.No. : CLDN11-1427H
Product Overview : Human CLDN11 full-length ORF ( NP_005593.2, 1 a.a. - 207 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 48.4 kDa
AA Sequence : MVATCLQVVGFVTSF VGWIGVIVTTSTNDW VVTCGYTIPTCRKLD ELGSKGLWADCVMAT GLYHCKPLVDILILP GYVQACRALMIAASV LGLPAILLLLTVLPC IRMGQEPGVAKYRRA QLAGVLLILLALCAL VATIWFPVCAHRETT IVSFGYSLYAGWIGA VLCLVGGCVILCCAG DAQAFGENRFYYTAG SSSPTHAKSAHV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing: :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : CLDN11 claudin 11 [ Homo sapiens ]
Official Symbol : CLDN11
Synonyms : OSP; OTM
Gene ID : 5010
mRNA Refseq : NM_005602.5
Protein Refseq : NP_005593.2
MIM : 601326
UniProt ID : O75508

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