Recombinant Human CLDN14 Protein, GST-tagged CLDN14-1430H

Recombinant Human CLDN14 Protein, GST-tagged

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Recombinant Human CLDN14 Protein, GST-tagged

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Cat.No. : CLDN14-1430H
Product Overview : Human CLDN14 full-length ORF ( NP_036262.1, 1 a.a. - 239 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 52.1 kDa
AA Sequence : MASTAVQLLGFLLSF LGMVGTLITTILPHW RRTAHVGTNILTAVS YLKGLWMECVWHSTG IYQCQIYRSLLALPQ DLQAARALMVISCLL SGIACACAVIGMKCT RCAKGTPAKTTFAIL GGTLFILAGLLCMVA VSWTTNDVVQNFYNP LLPSGMKFEIGQALY LGFISSSLSLIGGTL LCLSCQDEAPYRPYQ APPRATTTTANTAPA YQPPAAYKDNRAPSV TSATHSGYRLNDYV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing: :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : CLDN14 claudin 14 [ Homo sapiens ]
Official Symbol : CLDN14
Synonyms : CLDN14; claudin 14; DFNB29; claudin-14;
Gene ID : 23562
mRNA Refseq : NM_001146077
Protein Refseq : NP_001139549
MIM : 605608
UniProt ID : O95500

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