"CLP1" Related Products

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Recombinant Human CLP1 protein, MYC/DDK-tagged

Cat.No.: CLP1-185H
Product Overview: Recombinant Human CLP1, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description: This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene.
Source: HEK293
Species: Human
Tag: MYC/DDK
Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass: 47.5 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: CLP1 cleavage and polyadenylation factor I subunit 1 [ Homo sapiens ]
Official Symbol: CLP1
Synonyms: HEAB; hClp1; ATP/GTP-binding protein; CLP1; homolog of yeast CFIA subunit Clp1p; polyadenylation factor Clp1; polynucleotide kinase Clp1; pre-mRNA cleavage complex II protein Clp1
Gene ID: 10978
mRNA Refseq: NM_006831
Protein Refseq: NP_006822
MIM: 608757
UniProt ID: Q92989
Chromosome Location: 11q12
Pathway: Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; mRNA 3'-end processing, organism-specific biosystem; mRNA surveillance pathway, conserved biosystem
Function: ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; polydeoxyribonucleotide kinase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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