| Description : |
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m7GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m7GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
95.3 kDa |
| AA Sequence : |
MKRRTDPECTAPIKKQKKRVAELAL SLSSTSDDEPPSSVSHGAKASTTSL SGSDSETEGKQHSSDSFDDAFKADS LVEGTSSRYSMYNSVSQKLMAKMGF REGEGLGKYSQGRKDIVEASSQKGR RGLGLTLRGFDQELNVDWRDEPEPS ACEQVSWFPECTTEIPDTQEMSDWM VVGKRKMIIEDETEFCGEELLHSVL QCKSVFDVLDGEEMRRARTRANPYE MIRGVFFLNRAAMKMANMDFVFDRM FTNPRDSYGKPLVKDREAELLYFAD VCAGPGGFSEYVLWRKKWHAKGFGM TLKGPNDFKLEDFYSASSELFEPYY GEGGIDGDGDITRPENISAFRNFVL DNTDRKGVHFLMADGGFSVEGQENL QEILSKQLLLCQFLMALSIVRTGGH FICKTFDLFTPFSVGLVYLLYCCFE RVCLFKPITSRPANSERYVVCKGLK VGIDDVRDYLFAVNIKLNQLRNTDS DVNLVVPLEVIKGDHEFTDYMIRSN ESHCSLQIKALAKIHAFVQDTTLSE PRQAEIRKECLRLWGIPDQARVAPS SSDPKSKFFELIQGTEIDIFSYKPT LLTSKTLEKIRPVFDYRCMVSGSEQ KFLIGLGKSQIYTWDGRQSDRWIKL DLKTELPRDTLLSVEIVHELKGEGK AQRKISAIHILDVLVLNGTDVREQH FNQRIQLAEKFVKAVSKPSRPDMNP IRVKEVYRLEEMEKIFVRLEMKIIK GSSGTPKLSYTGRDDRHFVPMGLYI VRTVNEPWTMGFSKSFKKKFFYNKK TKDSTFDLPADSIAPFHICYYGRLF WEWGDGIRVHDSQKPQDQDKLSKED VLSFIQMHRATRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
