| Description : |
This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects. Two transcript variants that encode different isoforms have been identified for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
64.4 kDa |
| AA Sequence : |
MAWTARDRGALGLLLLGLCLCAAQR GPPGEQGPPGPPGPPGVPGIDGIDG DRGPKGPPGPPGPAGEPGKPGAPGK PGTPGADGLTGPDGSPGSIGSKGQK GEPGVPGSRGFPGRGIPGPPGPPGT AGLPGELGRVGPVGDPGRRGPPGPP GPPGPRGTIGFHDGDPLCPNACPPG RSGYPGLPGMRGHKGAKGEIGEPGR QGHKGEEGDQGELGEVGAQGPPGAQ GLRGITGIVGDKGEKGARGLDGEPG PQGLPGAPGDQGQRGPPGEAGPKGD RGAEGARGIPGLPGPKGDTGLPGVD GRDGIPGMPGTKGEPGKPGPPGDAG LQGLPGVPGIPGAKGVAGEKGSTGA PGKPGQMGNSGKPGQQGPPGEVGPR GPQGLPGSRGELGPVGSPGLPGKLG SLGSPGLPGLPGPPGLPGMKGDRGV VGEPGPKGEQGASGEEGEAGERGEL GDIGLPGPKGSAGNPGEPGLRGPEG SRGLPGVEGPRGPPGPRGVQGEQGA TGLPGVQGPPGRAPTDQHIKQVCMR VIQEHFAEMAASLKRPDSGATGLPG RPGPPGPPGPPGENGFPGQMGIRGL PGIKGPPGALGLRGPKGDLGEKGER GPPGRGPNGLPGAIGLPGDPGPASY GRNGRDGERGPPGVAGIPGVPGPPG PPGLPGFCEPASCTMQAGQRAFNKG PDPTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
