Recombinant Human COPS6 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: COPS6-2784H
• Product Overview: COPS6 MS Standard C13 and N15-labeled recombinant protein (NP_006824) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 36.2 kDa
• AA Sequence: MAAAAAAAAATNGTGGSSGMEVDAA VVPSVMACGVTGSVSVALHPLVILN ISDHWIRMRSQEGRPVQVIGALIGK QEGRNIEVMNSFELLSHTVEEKIII DKEYYYTKEEQFKQVFKELEFLGWY TTGGPPDPSDIHVHKQVCEIIESPL FLKLNPMTKHTDLPVSVFESVIDII NGEATMLFAELTYTLATEEAERIGV DHVARMTATGSGENSTVAEHLIAQH SAIKMLHSRVKLILEYVKASEAGEV PFNHEILREAYALCHCLPVLSTDKF KTDFYDQCNDVGLMAYLGTITKTCN TMNQFVNKFNVLYDRQGIGRRMRGL FFTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: COPS6 COP9 signalosome subunit 6 [ Homo sapiens (human) ]
• Official Symbol: COPS6
• Synonyms: COPS6; COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); COP9 signalosome complex subunit 6; COP9 subunit 6 (MOV34 homolog; 34 kD); CSN6; MOV34 34KD; SGN6; hVIP; H_NH0506M12.12; MOV34 homolog, 34 kD; signalosome subunit 6; vpr-interacting protein; COP9 subunit 6 (MOV34 homolog, 34 kD); JAB1-containing signalosome subunit 6; MOV34-34KD
• Gene ID: 10980
• mRNA Refseq: NM_006833
• Protein Refseq: NP_006824
• MIM: 614729
• UniProt ID: Q7L5N1