Recombinant Human Cornulin, His-tagged

• Cat.No.: CRNN-2029H
• Product Overview: Recombinant human CRNN protein with his tag was expressed inE.coliand purified by using conventional chromatography techniques, 55.7 kDa (515aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: CRNN is a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. It contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This protein, also Known as Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol.
• Purity: > 85% by SDS - PAGE.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP GVQTQGQATGSAWVSSYDRQ AESQSQERIS PQIQLSGQTE QTQKAGEGKR NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ TVEQDSSHQT GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQAVTGGHTQIQ AGSHTETVEQ DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP GGQAQTGAST EPGRQEWSST HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG ITARELYSYL RSTKP.
• Storage: can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CRNN cornulin [ Homo sapiens ]
• Synonyms: Cornulin; DRC1; PDRC1; SEP53; C1orf10; CRNN; tumor-related protein; 58 kDa heat shock protein; 53 kDa putative calcium-binding protein; squamous epithelial heat shock protein 53; 53 kDa squamous epithelial-induced stress protein; Squamous epithelial heat shock protein 53; Tumor-related protein; chromosome 1 open reading frame 10
• Gene ID: 49860
• mRNA Refseq: NM_016190
• Protein Refseq: NP_057274
• MIM: 611312
• UniProt ID: Q9UBG3
• Chromosome Location: 1q21
• Function: calcium ion binding