Recombinant Human-CoV(229E) S(1-1190) protein

• Cat.No.: hCoVS-112V
• Product Overview: Purified recombinant Human-CoV(229E) S(1-1190) protein was expressed in HEK293 cells.

Specification

• Description: S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
• Source: HEK293
• Species: Human-CoV
• Form: Each vial contains 100 ug purified protein (1mg/ml) in PBS (pH7.4).
• Purity: >95%
• Applications: WB standard, Ab ELISA, immunogen, etc.
• Usage: For research use only, not for use in diagnostic procedures.
• Storage: Store at -80 centigrade, Avoid freeze/thaw cycle.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: S
• Official Symbol: S
• Synonyms: HCoV229Egp2
• Gene ID: 918758
• Protein Refseq: NP_073551.1
• UniProt ID: P15423