Recombinant Human-CoV(229E) S(RBD) protein

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Recombinant Human-CoV(229E) S(RBD) protein

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Cat.No. : hCoVS-113V
Product Overview : Purified recombinant Human-CoV(229E) S(RBD) protein was expressed in HEK293 cells.
Description : S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Source : HEK293
Species : Human-CoV
Form : Each vial contains 100 ug purified protein (1mg/ml) in PBS (pH7.4).
Purity : >95%
Applications : WB standard, Ab ELISA, immunogen, etc.
Usage : For research use only, not for use in diagnostic procedures.
Storage : Store at -80 centigrade, Avoid freeze/thaw cycle.
Concentration : 1 mg/ml
Gene Name : S
Official Symbol : S
Synonyms : HCoV229Egp2
Gene ID : 918758
Protein Refseq : NP_073551.1
UniProt ID : P15423

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