Recombinant Human-CoV(229E) S(ΔTM) protein
Cat.No. : | hCoVS-111V |
Product Overview : | Purified recombinant Human-CoV(229E) S(ΔTM) protein was expressed in HEK293 cells. |
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Description : | S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. |
Source : | HEK293 |
Species : | Human-CoV |
Form : | Each vial contains 100 ug purified protein (1mg/ml) in PBS (pH7.4). |
Purity : | >95% |
Applications : | WB standard, Ab ELISA, immunogen, etc. |
Usage : | For research use only, not for use in diagnostic procedures. |
Storage : | Store at -80 centigrade, Avoid freeze/thaw cycle. |
Concentration : | 1 mg/ml |
Gene Name : | S |
Official Symbol : | S |
Synonyms : | HCoV229Egp2 |
Gene ID : | 918758 |
Protein Refseq : | NP_073551.1 |
UniProt ID : | P15423 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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