Recombinant Human CREB Binding Protein, GST-tagged

• Cat.No.: CREBBP-1581H
• Product Overview: Recombinant human CREBBP (518-1207; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 518-1207 a.a.
• Description: CREBBP has intrinsic histone acetyltransferase activity that acts as a scaffold to stabilize additional protein interactions with the transcription complex and acetylates both histone and non-histone proteins. CREBBP expressed as a nuclear protein that binds to cAMP-response element binding protein (CREB) and involved in the transcriptional coactivation of many different transcription factors. CREBBP plays a main role in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP also plays a critical role in the transmission of inductive signals from cell surface receptors to the transcriptional apparatus.
• Applications: Western Blot
• Molecular Weight: 140 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
• Purity: > 90 %
• Concentration: 0.1 ug/ul
• Sequences: 518-1207
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Adherens junction; Cell cycle; Huntington"s disease; Jak-STAT signaling pathway; Long-term potentiation; Notch signaling pathway; Pathways in cancer; Prostate cancer; Renal cell carcinoma; Melanogenesis; TGF-beta signaling pathway; Wnt signaling pathway; Gene Expression; Metabolism of lipids and lipoproteins

Gene Information

• Gene Name: CREBBP CREB binding protein [ Homo sapiens ]
• Official Symbol: CREBBP
• Synonyms: CREBBP; CREB binding protein; CBP; RSTS; KAT3A; Rubinstein-Taybi syndrome; RTS; CREB-binding protein; OTTHUMP00000159801; NP_001073315.1; EC 2.3.1.48; NP_004371.2
• Gene ID: 1387
• mRNA Refseq: NM_004380
• Protein Refseq: NP_004371
• MIM: 600140
• UniProt ID: Q92793
• Chromosome Location: 16p13.3
• Function: MyoD binding; SMAD binding; acetyltransferase activity; histone acetyltransferase activity; metal ion binding; p53 binding; peroxisome proliferator activated receptor binding; signal transducer activity; transcription coactivator activity; transcription coactivator activity; transcription factor activity; transferase activity; zinc ion binding