Recombinant Human CRTC2 Protein, GST-tagged

• Cat.No.: CRTC2-1918H
• Product Overview: Human CRTC2 full-length ORF ( NP_859066.1, 1 a.a. - 693 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 99.7 kDa
• AA Sequence: MATSGANGPGSATASASNPRKFSEK IALQKQRQAEETAAFEEVMMDIGST RLQAQKLRLAYTRSSHYGGSLPNVN QIGSGLAEFQSPLHSPLDSSRSTRH HGLVERVQRDPRRMVSPLRRYTRHI DSSPYSPAYLSPPPESSWRRTMAWG NFPAEKGQLFRLPSALNRTSSDSAL HTSVMNPSPQDTYPGPTPPSILPSR RGGILDGEMDPKVPAIEENLLDDKH LLKPWDAKKLSSSSSRPRSCEVPGI NIFPSPDQPANVPVLPPAMNTGGSL PDLTNLHFPPPLPTPLDPEETAYPS LSGGNSTSNLTHTMTHLGISRGMGL GPGYDAPGLHSPLSHPSLQSSLSNP NLQASLSSPQPQLQGSHSHPSLPAS SLARHVLPTTSLGHPSLSAPALSSS SSSSSTSSPVLGAPSYPASTPGASP HHRRVPLSPLSLLAGPADARRSQQQ LPKQFSPTMSPTLSSITQGVPLDTS KLSTDQRLPPYPYSSPSLVLPTQPH TPKSLQQPGLPSQSCSVQSSGGQPP GRQSHYGTPYPPGPSGHGQQSYHRP MSDFNLGNLEQFSMESPSASLVLDP PGFSEGPGFLGGEGPMGGPQDPHTF NHQNLTHCSRHGSGPNIILTGDSSP GFSKEIAAALAGVPGFEVSAAGLEL GLGLEDELRMEPLGLEGLNMLSDPC ALLPDPAVEESFRSDRLQ
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CRTC2 CREB regulated transcription coactivator 2 [ Homo sapiens ]
• Official Symbol: CRTC2
• Synonyms: CRTC2; CREB regulated transcription coactivator 2; CREB-regulated transcription coactivator 2; TORC2; transducer of regulated cAMP response element-binding protein (CREB) 2; TORC-2
• Gene ID: 200186
• mRNA Refseq: NM_181715
• Protein Refseq: NP_859066
• MIM: 608972
• UniProt ID: Q53ET0