Recombinant Human CSE1L Protein, GST-tagged

• Cat.No.: CSE1L-1959H
• Product Overview: Human CSE1L full-length ORF ( ENSP00000343253, 1 a.a. - 195 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 49.1 kDa
• AA Sequence: MELSDANLQTLTEYLKKTLDPDPAI RRPAEKFLESVEGNQNYPLLLLTLL EKSQDNVIKVCASVTFKNYIKRNWR IVEDEPNKICEADRVAIKANIVHLM LSSPEQIQKQLSDAISIIGREDFPQ KWPDLLTEMVNRFQSGDFHVINGVL RTAHSLFKRYRHEFKSNELWTEIKL VLDAFALPLTNLFKVWNASW
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CSE1L CSE1 chromosome segregation 1-like (yeast) [ Homo sapiens ]
• Official Symbol: CSE1L
• Synonyms: CSE1L; CSE1 chromosome segregation 1-like (yeast); chromosome segregation 1 (yeast homolog) like; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein; MGC117283; MGC130036; MGC130037
• Gene ID: 1434
• mRNA Refseq: NM_001256135
• Protein Refseq: NP_001243064
• MIM: 601342
• UniProt ID: P55060