Recombinant Human CSE1L Protein, GST-tagged

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Recombinant Human CSE1L Protein, GST-tagged

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Cat.No. : CSE1L-1959H
Product Overview : Human CSE1L full-length ORF ( ENSP00000343253, 1 a.a. - 195 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 49.1 kDa
AA Sequence : MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIKV CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM LSSPEQIQKQ LSDAISIIGR EDFPQKWPDL LTEMVNRFQS GDFHVINGVL RTAHSLFKRY RHEFKSNELW TEIKLVLDAF ALPLTNLFKV WNASW
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing: :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : CSE1L CSE1 chromosome segregation 1-like (yeast) [ Homo sapiens ]
Official Symbol : CSE1L
Synonyms : CSE1L; CSE1 chromosome segregation 1-like (yeast); chromosome segregation 1 (yeast homolog) like; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein; MGC117283; MGC130036; MGC130037;
Gene ID : 1434
mRNA Refseq : NM_001256135
Protein Refseq : NP_001243064
MIM : 601342
UniProt ID : P55060

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